Relationship between blood pressure and frailty in older hypertensive outpatients

Aging Clin Exp Res. 2017 Oct;29(5):1049-1053. doi: 10.1007/s40520-016-0684-5. Epub 2016 Nov 21.

Abstract

Background: The benefits and risks of treating hypertension in old and frail patients are debated.

Aim: The aim of the present study is to measure the frailty status in older patients with hypertension and determine the relationships existing between blood pressure (BP) values and frailty.

Methods: Frailty was retrospectively assessed by using the frailty index (FI) in 56 hypertensive old outpatients. Patients with an FI > 0.25 were classified as frail.

Results: Forty-five out of 56 (80%) had a FI > 0.25. A statistically significant inverse correlation was found between FI and systolic BP (r = -0.319, p = 0.016), orthostatic systolic BP (r = -0.408, p = 0.002), orthostatic diastolic BP (r = -0.299, p = 0.025), and orthostatic pulse pressure (r = -0.297, p = 0.026).

Discussion: Frailer subjects appear as over-treated according to current European guidelines.

Conclusions: FI can play an important role in the clinical setting by supporting the identification of subjects at risk and allowing an improved provision of adapted and personalized care.

Keywords: Blood pressure; Elderly; Frailty; Frailty index; Hypertension.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Antihypertensive Agents / adverse effects
  • Blood Pressure
  • Blood Pressure Determination
  • Female
  • Frail Elderly*
  • Frailty / complications*
  • Frailty / diagnosis
  • Geriatric Assessment
  • Humans
  • Hypertension / complications*
  • Hypertension / drug therapy
  • Male
  • Outpatients / statistics & numerical data
  • Retrospective Studies

Substances

  • Antihypertensive Agents