Eukaryotic Ribosome as a Target for Cardiovascular Disease

Simone Pellegrino; Gulnara Yusupova

doi:10.1016/j.chembiol.2016.11.004

Eukaryotic Ribosome as a Target for Cardiovascular Disease

Cell Chem Biol. 2016 Nov 17;23(11):1319-1321. doi: 10.1016/j.chembiol.2016.11.004.

Authors

Simone Pellegrino¹, Gulnara Yusupova²

Affiliations

¹ Department of Integrated Structural Biology, Institute of Genetics and Molecular and Cellular Biology, 1 rue Laurent Fries, BP 10142, Illkirch 67404, France; Centre National de Recherche Scientifique (CNRS) UMR 7104, Illkirch 67404, France; Institut National de Santé et de Recherche Médicale (INSERM) U964, Illkirch 67404, France; Université de Strasbourg, Strasbourg 67081, France.
² Department of Integrated Structural Biology, Institute of Genetics and Molecular and Cellular Biology, 1 rue Laurent Fries, BP 10142, Illkirch 67404, France; Centre National de Recherche Scientifique (CNRS) UMR 7104, Illkirch 67404, France; Institut National de Santé et de Recherche Médicale (INSERM) U964, Illkirch 67404, France; Université de Strasbourg, Strasbourg 67081, France. Electronic address: gula@igbmc.fr.

PMID: 27863217
DOI: 10.1016/j.chembiol.2016.11.004

Abstract

Cardiovascular diseases have been associated with genetic variants and increased plasma level of the secreted protein PCSK9. In this issue of Cell Chemical Biology, Petersen et al. (2016) describe an inhibitor of PCSK9 secretion in human cells that, surprisingly, targets the 80S ribosome.

Publication types

Comment

MeSH terms

Cardiovascular Diseases*
Eukaryota*
Humans
Proprotein Convertase 9
Protein Biosynthesis
Ribosomes
Secretagogues

Substances

Secretagogues
PCSK9 protein, human
Proprotein Convertase 9