Branched Gold Nanoparticle Coating of Clostridium novyi-NT Spores for CT-Guided Intratumoral Injection

Wooram Park; Soojeong Cho; Xiaoke Huang; Andrew C Larson; Dong-Hyun Kim

doi:10.1002/smll.201602722

Branched Gold Nanoparticle Coating of Clostridium novyi-NT Spores for CT-Guided Intratumoral Injection

Small. 2017 Feb;13(5):10.1002/smll.201602722. doi: 10.1002/smll.201602722. Epub 2016 Nov 15.

Authors

Wooram Park¹, Soojeong Cho¹, Xiaoke Huang¹, Andrew C Larson^{1

2

3

4

5}, Dong-Hyun Kim^{1

2}

Affiliations

¹ Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
² Robert H. Lurie Comprehensive Cancer Center, Chicago, IL, 60611, USA.
³ Department of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA.
⁴ Department of Electrical Engineering and Computer Science, Northwestern University, Evanston, IL, 60208, USA.
⁵ International Institute of Nanotechnology (IIN), Northwestern University, Evanston, IL, 60208, USA.

Abstract

Branched gold nanoparticle (BGNP)-coated Clostridium novyi-NT (C. novyi-NT) spores are developed for computed tomography (CT)-guided bacteriolytic tumor therapy. The BGNP-coated spores are successfully injected into a tumor site under CT image guidance. As a result, a strong antitumor effect is observed in a PC3 prostate tumor-bearing mouse model.

Keywords: Clostridium novyi-NT; bacteriolytic tumor therapy; computed tomography image-guided therapy; gold nanoparticles.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Clostridium / physiology
Colloids / chemistry
Electrochemistry
Gold / chemistry*
Injections, Intralesional
Metal Nanoparticles / chemistry*
Spores, Bacterial / chemistry*
Ultrasonics

Substances

Colloids
Gold

Abstract

Publication types

MeSH terms

Substances

Grants and funding