FUT2 non-secretor status is associated with Type 1 diabetes susceptibility in Japanese children

K Ihara; C Fukano; T Ayabe; M Fukami; T Ogata; T Kawamura; T Urakami; N Kikuchi; I Yokota; K Takemoto; T Mukai; A Nishii; T Kikuchi; T Mori; N Shimura; G Sasaki; R Kizu; N Takubo; S Soneda; T Fujisawa; R Takaya; Z Kizaki; S Kanzaki; K Hanaki; N Matsuura; Y Kasahara; K Kosaka; T Takahashi; K Minamitani; S Matsuo; H Mochizuki; K Kobayashi; A Koike; R Horikawa; S Teno; K Tsubouchi; T Mochizuki; Y Igarashi; S Amemiya; S Sugihara; Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes (JSGIT)

doi:10.1111/dme.13288

FUT2 non-secretor status is associated with Type 1 diabetes susceptibility in Japanese children

Diabet Med. 2017 Apr;34(4):586-589. doi: 10.1111/dme.13288. Epub 2016 Dec 15.

Authors

K Ihara^{1

2}, C Fukano¹, T Ayabe³, M Fukami³, T Ogata^{3

4}, T Kawamura⁵, T Urakami⁶, N Kikuchi⁷, I Yokota^{8

9}, K Takemoto^{10

11}, T Mukai^{12

13}, A Nishii¹⁴, T Kikuchi^{15

16}, T Mori^{17

18}, N Shimura¹⁹, G Sasaki²⁰, R Kizu²¹, N Takubo^{22

23}, S Soneda²⁴, T Fujisawa²⁵, R Takaya²⁶, Z Kizaki²⁷, S Kanzaki²⁸, K Hanaki²⁹, N Matsuura^{30

31}, Y Kasahara³², K Kosaka³³, T Takahashi³⁴, K Minamitani³⁵, S Matsuo³⁶, H Mochizuki³⁷, K Kobayashi³⁸, A Koike³⁹, R Horikawa⁴⁰, S Teno⁴¹, K Tsubouchi⁴², T Mochizuki^{43

44}, Y Igarashi⁴⁵, S Amemiya¹⁵, S Sugihara⁴⁶; Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes (JSGIT)

Affiliations

¹ Department of Paediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
² Department of Paediatrics, Oita University School of Medicine, Yufu, Japan.
³ Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Tokyo, Japan.
⁴ Department of Paediatrics, Hamamatsu University School of Medicine, Hamamatsu, Japan.
⁵ Department of Paediatrics, Osaka City University Hospital, Osaka, Japan.
⁶ Department of Paediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.
⁷ Department of Paediatrics, Yokohama City Minato Red Cross Hospital, Yokohama, Japan.
⁸ Department of Clinical Laboratory, Shikoku Medical Center for Children and Adults, Zentsuji, Japan.
⁹ Department of Paediatrics, Graduate School of Medical Sciences Tokushima University, Tokushima, Japan.
¹⁰ Department of Paediatrics, Ehime University Hospital, Toon, Japan.
¹¹ Department of Paediatrics, Sumitomo Besshi Hospital, Niihama, Japan.
¹² Department of Paediatrics, Asahikawa Medical University Hospital, Asahikawa, Japan.
¹³ Department of Paediatrics, Asahikawa-Kosei General Hospital, Asahikawa, Japan.
¹⁴ Department of Paediatrics, JR Sendai Hospital, Sendai, Japan.
¹⁵ Department of Paediatrics, Saitama Medical University Hospital, Saitama, Japan.
¹⁶ Department of Paediatrics, Niigata University Medical and Dental Hospital, Niigata, Japan.
¹⁷ Department of Paediatrics, Nagano Red Cross Hospital, Nagano, Japan.
¹⁸ Department of Paediatrics, Shinshu Ueda Medical Centre, Ueda, Japan.
¹⁹ Department of Paediatrics, Dokkyo Medical University Hospital, Shimotsuga, Japan.
²⁰ Department of Paediatrics, Tokyo Dental College Ichikawa General Hospital, Ichikawa, Japan.
²¹ Department of Paediatrics, Yokosuka Kyosai Hospital, Yokosuka, Japan.
²² Department of Pediatrics, Kitasato University Hospital, Sagamihara, Japan.
²³ Department of Paediatrics and Adolescent Medicine, Juntendo University School of Medicine, Tokyo, Japan.
²⁴ Department of Paediatrics, St Marianna University School of Medicine, Kawasaki, Japan.
²⁵ Department of Paediatrics, National Mie Hospital, Tsu, Japan.
²⁶ Department of Paediatrics, Osaka Medical College, Takatsuki, Japan.
²⁷ Department of Paediatrics, Japanese Red Cross Kyoto Daiichi Hospital, Kyoto, Japan.
²⁸ Department of Paediatrics, Tottori University Faculty of Medicine, Yonago, Japan.
²⁹ Department of Paediatrics, Tottori Prefectural Kousei Hospital, Kurayoshi, Japan.
³⁰ Department of Paediatrics, Teine Keijinkai Hospital, Sapporo, Japan.
³¹ Department of Early Childhood Care and Education, Seitoku University Junior College, Matsudo, Japan.
³² Department of Paediatrics, Kanazawa University, Kanazawa, Japan.
³³ Department of Paediatrics, University Hospital, Kyoto Prefectural University of Medicine, Kyoto, Japan.
³⁴ Takahashi Clinic, Kobe, Japan.
³⁵ Department of Paediatrics, Teikyo University Chiba Medical Center, Ichihara, Japan.
³⁶ Matsuo Kodomo Clinic, Kyoto, Japan.
³⁷ Department of Metabolism and Endocrinology, Saitama Children's Medical Centre, Saitama, Japan.
³⁸ Department of Paediatrics, University of Yamanashi Hospital, Chuo, Japan.
³⁹ Miyanosawa Koike Child Clinic, Sapporo, Japan.
⁴⁰ Division of Endocrinology and Metabolism, Department of Medical Subspecialties, National Medical Centre for Children and Mothers, Tokyo, Japan.
⁴¹ Teno Clinic, Izumo, Japan.
⁴² Department of Paediatrics, Chuno Kosei Hospital, Seki, Japan.
⁴³ Department of Paediatrics, Osaka City General Hospital, Osaka, Japan.
⁴⁴ Department of Paediatrics, Osaka Police Hospital, Osaka, Japan.
⁴⁵ Igarashi Children's Clinic, Sendai, Japan.
⁴⁶ Department of Paediatrics, Tokyo Women's Medical University Medical Centre East, Tokyo, Japan.

PMID: 27859559
DOI: 10.1111/dme.13288

Abstract

Aim: To examine the contribution of the FUT2 gene and ABO blood type to the development of Type 1 diabetes in Japanese children.

Methods: We analysed FUT2 variants and ABO genotypes in a total of 531 Japanese children diagnosed with Type 1 diabetes and 448 control subjects. The possible association of FUT2 variants and ABO genotypes with the onset of Type 1 diabetes was statistically examined.

Results: The se2 genotype (c.385A>T) of the FUT2 gene was found to confer susceptibility to Type 1A diabetes in a recessive effects model [odds ratio for se2/se2, 1.68 (95% CI 1.20-2.35); corrected P value = 0.0075].

Conclusions: The FUT2 gene contributed to the development of Type 1 diabetes in the present cohort of Japanese children.

MeSH terms

ABO Blood-Group System / genetics
Asian People / genetics
Case-Control Studies
Diabetes Mellitus, Type 1 / genetics*
Fucosyltransferases / genetics*
Galactoside 2-alpha-L-fucosyltransferase
Genetic Predisposition to Disease
Humans
Japan

Substances

ABO Blood-Group System
Fucosyltransferases