Contribution of Maternal Immunity to Decreased Rotavirus Vaccine Performance in Low- and Middle-Income Countries

Clin Vaccine Immunol. 2017 Jan 5;24(1):e00405-16. doi: 10.1128/CVI.00405-16. Print 2017 Jan.

Abstract

The role of maternal immunity, received by infants either transplacentally or orally from breast milk, in rotavirus vaccine (RV) performance is evaluated here. Breastfeeding withholding has no effect on vaccine responses, but higher levels of transplacental rotavirus-specific IgG antibody contribute to reduced vaccine seroconversion. The gaps in knowledge on the factors associated with low RV efficacy in low- and middle-income countries (LMIC) remain, and further research is needed to shed more light on these issues.

Keywords: immunization; low- and middle-income countries; maternal; rotavirus.

Publication types

  • Review

MeSH terms

  • Antibodies, Viral / blood
  • Developing Countries
  • Humans
  • Immunity, Maternally-Acquired*
  • Immunoglobulin G / blood
  • Rotavirus Infections / immunology
  • Rotavirus Infections / prevention & control*
  • Rotavirus Vaccines / administration & dosage*
  • Rotavirus Vaccines / immunology*
  • Treatment Outcome

Substances

  • Antibodies, Viral
  • Immunoglobulin G
  • Rotavirus Vaccines