Cholesterol: An Achilles' Heel for Glioblastoma?

Zhenyi An; William A Weiss

doi:10.1016/j.ccell.2016.10.011

Cholesterol: An Achilles' Heel for Glioblastoma?

Cancer Cell. 2016 Nov 14;30(5):653-654. doi: 10.1016/j.ccell.2016.10.011.

Authors

Zhenyi An¹, William A Weiss²

Affiliations

¹ Departments of Neurology, Pediatrics, and Neurosurgery, Brain Tumor Research Center, and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.
² Departments of Neurology, Pediatrics, and Neurosurgery, Brain Tumor Research Center, and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: waweiss@gmail.com.

PMID: 27846382
DOI: 10.1016/j.ccell.2016.10.011

Abstract

In this issue of Cancer Cell, Villa et al. report that survival of glioblastoma cells is dependent on uptake of cholesterol. A synthetic agonist of the Liver X receptor depleted cholesterol in GBM cells, slowing growth of GBM xenografts.

MeSH terms

Cholesterol*
Glioblastoma*
Humans

Substances

Cholesterol