Taurolidine in Pediatric Home Parenteral Nutrition Patients

Pediatr Infect Dis J. 2017 Feb;36(2):233-235. doi: 10.1097/INF.0000000000001404.

Abstract

To reduce the incidence of catheter-related bloodstream infections in home parenteral nutrition patients, the use of taurolidine was introduced in the Sophia Children's Hospital in 2011. This introduction led to a reduction in catheter-related bloodstream infections: 12.7/1000 catheter days before the use of taurolidine, compared with 4.3/1000 catheter days afterwards (n = 7) [relative risk = 0.36, 95% confidence interval: 0.20-0.65 (P = 0.018)].

MeSH terms

  • Anti-Infective Agents / administration & dosage
  • Anti-Infective Agents / therapeutic use*
  • Bacteremia* / drug therapy
  • Bacteremia* / epidemiology
  • Bacteremia* / prevention & control
  • Catheter-Related Infections* / drug therapy
  • Catheter-Related Infections* / epidemiology
  • Catheter-Related Infections* / prevention & control
  • Child, Preschool
  • Humans
  • Infant
  • Infant, Newborn
  • Parenteral Nutrition, Home / adverse effects
  • Parenteral Nutrition, Home / methods
  • Parenteral Nutrition, Home / statistics & numerical data*
  • Retrospective Studies
  • Taurine / administration & dosage
  • Taurine / analogs & derivatives*
  • Taurine / therapeutic use
  • Thiadiazines / administration & dosage
  • Thiadiazines / therapeutic use*

Substances

  • Anti-Infective Agents
  • Thiadiazines
  • Taurine
  • taurolidine