Abstract
To reduce the incidence of catheter-related bloodstream infections in home parenteral nutrition patients, the use of taurolidine was introduced in the Sophia Children's Hospital in 2011. This introduction led to a reduction in catheter-related bloodstream infections: 12.7/1000 catheter days before the use of taurolidine, compared with 4.3/1000 catheter days afterwards (n = 7) [relative risk = 0.36, 95% confidence interval: 0.20-0.65 (P = 0.018)].
MeSH terms
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Anti-Infective Agents / administration & dosage
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Anti-Infective Agents / therapeutic use*
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Bacteremia* / drug therapy
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Bacteremia* / epidemiology
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Bacteremia* / prevention & control
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Catheter-Related Infections* / drug therapy
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Catheter-Related Infections* / epidemiology
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Catheter-Related Infections* / prevention & control
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Child, Preschool
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Humans
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Infant
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Infant, Newborn
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Parenteral Nutrition, Home / adverse effects
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Parenteral Nutrition, Home / methods
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Parenteral Nutrition, Home / statistics & numerical data*
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Retrospective Studies
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Taurine / administration & dosage
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Taurine / analogs & derivatives*
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Taurine / therapeutic use
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Thiadiazines / administration & dosage
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Thiadiazines / therapeutic use*
Substances
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Anti-Infective Agents
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Thiadiazines
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Taurine
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taurolidine