Low serum vitamin D levels and anti-N-methyl-d-aspartate receptor encephalitis: A case-control study

Abstract

Background: Low vitamin D levels are associated with autoimmunity, but the relationship with anti-N-Methyl-d-aspartate receptor (anti-NMDAR) encephalitis is unknown.

Methods: 25(OH) D levels and clinical and cerebrospinal fluid parameters were evaluated in 30 patients with anti-NMDAR encephalitis and compared with 90 age-, sex-, and season-matched healthy controls.

Results: 25(OH)D levels were lower in patients with anti-NMDAR encephalitis compared to controls (43.89 ± 17.91 vs 64.24 ± 24.38 nmol/L, p < 0.001), especially for females (vs males, p = 0.008), aged ≤30 years (vs > 30 years, p = 0.002), severe impairment (mRS ≥ 5) (vs mRS < 5, p = 0.018), and limited treatment responses (vs favorable treatment, p = 0.02). Serum 25(OH)D levels were associated with age (r = 0.393, p = 0.032), and mRS (r = -0.417, p = 0.022).

Conclusions: Our data showed that serum 25(OH)D levels were reduced in patients with anti-NMDAR encephalitis.

Keywords: 25-hydroxyvitamin D; Anti-N-Methyl-d-aspartate receptor encephalitis; Biomarker; Immune effects.