Abstract
Two new triterpene saponins, clinopodiside VI (1) and saikosaponin c (2), along with six known saikosaponins (3-8), were isolated from the plant of Clinopodium polycephalum. Compounds 1-3 showed moderate inhibition against H9c2 cell damage induced by H2O2.
Keywords:
Clinopodium polycephalum; cardioprotective activity; triterpene saponins.
MeSH terms
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Cardiotonic Agents / chemistry
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Cardiotonic Agents / isolation & purification*
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Cardiotonic Agents / pharmacology*
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology*
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Hydrogen Peroxide / pharmacology
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Lamiaceae / chemistry*
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Oleanolic Acid / analogs & derivatives
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Oleanolic Acid / chemistry
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Oleanolic Acid / isolation & purification*
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Oleanolic Acid / pharmacology*
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Saponins / pharmacology
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Triterpenes / chemistry
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Triterpenes / isolation & purification*
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Triterpenes / pharmacology*
Substances
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Cardiotonic Agents
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Drugs, Chinese Herbal
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Saponins
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Triterpenes
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clinopodiside VI
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oleanane
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Oleanolic Acid
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Hydrogen Peroxide
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saikosaponin D