Recurrent transient global amnesia as presenting symptoms of CADASIL

Luca Pradotto; Laura Orsi; Monica Mencarelli; Marcella Caglio; Danilo Lauro; Alessandra Milesi; Anna Di Blasio; Alessandro Mauro

doi:10.1002/ccr3.666

Recurrent transient global amnesia as presenting symptoms of CADASIL

Clin Case Rep. 2016 Sep 28;4(11):1045-1048. doi: 10.1002/ccr3.666. eCollection 2016 Nov.

Authors

Luca Pradotto¹, Laura Orsi², Monica Mencarelli³, Marcella Caglio⁴, Danilo Lauro⁵, Alessandra Milesi¹, Anna Di Blasio³, Alessandro Mauro⁶

Affiliations

¹ Division of Neurology and Neurorehabilitation San Giuseppe Hospital IRCCS Istituto Auxologico Italiano Piancavallo VB Italy.
² Neurologic Division 1 Department of Neuroscience and Mental Health AOU Città della Salute e della Scienza di Torino Turin Italy.
³ Laboratory of Molecular Biology IRCCS Istituto Auxologico Italiano Milan Italy.
⁴ Department of Neuroscience University of Turin Turin Italy.
⁵ Surgical Dermatology Department of Oncology AOU Città della Salute e della Scienza di Torino Turin Italy.
⁶ Division of Neurology and Neurorehabilitation San Giuseppe HospitalI RCCS Istituto Auxologico Italiano Piancavallo VB Italy; Department of Neuroscience University of Turin Turin Italy.

Abstract

Despite transient global amnesia is considered unusual in Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and causal relation is still unclear, this report suggests to consider CADASIL in those patients with recurrent transient global amnesia, especially when MRI shows multifocal hyperintensities affecting the cerebral white matter or when it is followed by cognitive decline.

Keywords: CADASIL; NOTCH3 gene mutation; cognitive impairment; dementia; leukoaraiosis; microbleeds; transient global amnesia.

Publication types

Case Reports