Arginine Arms T Cells to Thrive and Survive

Rigel J Kishton; Madhusudhanan Sukumar; Nicholas P Restifo

doi:10.1016/j.cmet.2016.10.019

Arginine Arms T Cells to Thrive and Survive

Cell Metab. 2016 Nov 8;24(5):647-648. doi: 10.1016/j.cmet.2016.10.019.

Authors

Rigel J Kishton¹, Madhusudhanan Sukumar¹, Nicholas P Restifo²

Affiliations

¹ Center for Cell-Based Therapy, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA; Surgery Branch, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
² Center for Cell-Based Therapy, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA; Surgery Branch, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA. Electronic address: restifo@nih.gov.

Abstract

A clear role for cellular metabolism in regulating immune cell function has recently been established. In a recent issue of Cell, Geiger et al. (2016) demonstrate a role for intracellular arginine abundance in T cells for the promotion of oxidative metabolism, increased cell viability, persistence, and in vivo antitumor response.

Published by Elsevier Inc.

Publication types

Comment

MeSH terms

Arginine*
Cell Survival
T-Lymphocytes / immunology*

Substances

Arginine

Grants and funding

Z01 BC010763-03/Intramural NIH HHS/United States