Biscogniauxone, a New Isopyrrolonaphthoquinone Compound from the Fungus Biscogniauxia mediterranea Isolated from Deep-Sea Sediments

Mar Drugs. 2016 Nov 2;14(11):204. doi: 10.3390/md14110204.

Abstract

The properties and the production of new metabolites from the fungal strain LF657 isolated from the Herodotes Deep (2800 m depth) in the Mediterranean Sea are reported in this study. The new isolate was identified as Biscogniauxia mediterranea based on ITS1-5.8S-ITS2 and 28S rRNA gene sequences. A new isopyrrolonaphthoquinone with inhibitory activity against glycogen synthase kinase (GSK-3β) was isolated from this fungus. This is the first report of this class of compounds from a fungus isolated from a deep-sea sediment, as well as from a Biscogniauxia species.

Keywords: Biscogniauxia mediterranea; acetylcholinesterase; deep sea; glycogen synthase kinase; marine fungi.

MeSH terms

  • Benzoquinones / chemistry*
  • Benzoquinones / pharmacology*
  • Fungi / chemistry*
  • Fungi / genetics
  • Geologic Sediments / microbiology*
  • Glycogen Synthase Kinase 3 beta / antagonists & inhibitors
  • Mediterranean Sea
  • RNA, Ribosomal / genetics
  • Seawater / microbiology*
  • Xylariales / chemistry*
  • Xylariales / genetics

Substances

  • Benzoquinones
  • RNA, Ribosomal
  • quinone
  • Glycogen Synthase Kinase 3 beta