Prodrug approach: An overview of recent cases

Valentina Abet; Fabiana Filace; Javier Recio; Julio Alvarez-Builla; Carolina Burgos

doi:10.1016/j.ejmech.2016.10.061

Prodrug approach: An overview of recent cases

Eur J Med Chem. 2017 Feb 15:127:810-827. doi: 10.1016/j.ejmech.2016.10.061. Epub 2016 Oct 29.

Authors

Valentina Abet¹, Fabiana Filace¹, Javier Recio¹, Julio Alvarez-Builla², Carolina Burgos³

Affiliations

¹ Departamento de Química Orgánica, Universidad de Alcalá, 28871 Alcalá de Henares, Madrid, Spain.
² Departamento de Química Orgánica, Universidad de Alcalá, 28871 Alcalá de Henares, Madrid, Spain. Electronic address: julio.alvarez@uah.es.
³ Departamento de Química Orgánica, Universidad de Alcalá, 28871 Alcalá de Henares, Madrid, Spain. Electronic address: carolina.burgos@uah.es.

PMID: 27823878
DOI: 10.1016/j.ejmech.2016.10.061

Abstract

In this review we highlight the most modern trends in the prodrug strategy. In drug research and development, the prodrug concept has found a number of useful applications. Selected examples of this approach are provided in this paper and they are classified according to the aim of their design.

Keywords: Bioprecursors; Carrier-linked prodrug; Prodrug.

Publication types

Review

MeSH terms

Absorption, Physicochemical
Animals
Cell Membrane Permeability
Drug Discovery / methods*
Humans
Prodrugs* / adverse effects
Prodrugs* / chemistry
Prodrugs* / metabolism
Solubility
Water / chemistry

Substances

Prodrugs
Water