Osteoradionecrosis and intensity modulated radiation therapy: An overview

Francesca De Felice; Daniela Musio; Vincenzo Tombolini

doi:10.1016/j.critrevonc.2016.08.017

Osteoradionecrosis and intensity modulated radiation therapy: An overview

Crit Rev Oncol Hematol. 2016 Nov:107:39-43. doi: 10.1016/j.critrevonc.2016.08.017. Epub 2016 Sep 2.

Authors

Francesca De Felice¹, Daniela Musio², Vincenzo Tombolini³

Affiliations

¹ Department of Radiotherapy, Policlinico Umberto I "Sapienza" University of Rome, Viale Regina Elena 326, 00161 Rome, Italy. Electronic address: fradefelice@hotmail.it.
² Department of Radiotherapy, Policlinico Umberto I "Sapienza" University of Rome, Viale Regina Elena 326, 00161 Rome, Italy.
³ Department of Radiotherapy, Policlinico Umberto I "Sapienza" University of Rome, Viale Regina Elena 326, 00161 Rome, Italy; Spencer-Lorillard Foundation, Viale Regina Elena 262, Rome, Italy.

PMID: 27823650
DOI: 10.1016/j.critrevonc.2016.08.017

Abstract

Osteoradionecrosis (ORN) is an ongoing topic, especially about its definition, pathogenesis, staging system and management algorithm. But what about its real incidence in intensity modulated radiotherapy (IMRT) era? This paper discusses the mandible in radiation therapy planning as organ at risk and reviews the literature for evidence of radiation damage, discussing likely dose constraints and the use of IMRT to reduce radiation dose to this structure. PubMed search was performed.

Keywords: Dose; Head and neck cancer; IMRT; Mandible; Osteoradionecrosis; Toxicity.

Publication types

Review

MeSH terms

Humans
Mandibular Diseases / etiology
Osteoradionecrosis*
Radiotherapy Dosage
Radiotherapy, Intensity-Modulated / adverse effects
Risk Factors