Abstract
Intracellular signaling pathways were investigated in skeletal muscle cells at the early stages of alcohol addiction manifestations. No muscle fiber atrophy was observed in m. vastus lateralis of male patients. No significant changes in the signaling mechanisms that control protein degradation were detected as well. However, the concentration of the insulin-like growth factor (IGF-1) in blood plasma as well as the content of markers of intracellular signaling pathways regulating protein synthesis were significantly reduced compared to the control group.
MeSH terms
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Alcoholic Intoxication / metabolism*
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Alcoholic Intoxication / pathology
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Alcoholism / metabolism*
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Alcoholism / pathology
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Analysis of Variance
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Atrophy
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Elongation Factor 2 Kinase / metabolism
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Humans
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Insulin Receptor Substrate Proteins / metabolism
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Insulin-Like Growth Factor I / metabolism
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Male
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Middle Aged
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Muscle Fibers, Skeletal / metabolism*
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Muscle Fibers, Skeletal / pathology
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Phosphorylation
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Proteolysis / drug effects
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RNA, Messenger / metabolism
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Ribosomal Protein S6 Kinases, 70-kDa / metabolism
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Ribosomal Protein S6 Kinases, 90-kDa / metabolism
Substances
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IGF1 protein, human
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IRS1 protein, human
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Insulin Receptor Substrate Proteins
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RNA, Messenger
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Insulin-Like Growth Factor I
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EEF2K protein, human
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Ribosomal Protein S6 Kinases, 70-kDa
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Ribosomal Protein S6 Kinases, 90-kDa
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Elongation Factor 2 Kinase