Initial experiments with gel-water: towards MRI-linac dosimetry and imaging

Australas Phys Eng Sci Med. 2016 Dec;39(4):921-932. doi: 10.1007/s13246-016-0495-1. Epub 2016 Nov 4.

Abstract

Tracking the position of a moving radiation detector in time and space during data acquisition can replicate 4D image-guided radiotherapy (4DIGRT). Magnetic resonance imaging (MRI)-linacs need MRI-visible detectors to achieve this, however, imaging solid phantoms is an issue. Hence, gel-water, a material that provides signal for MRI-visibility, and which will in future work, replace solid water for an MRI-linac 4DIGRT quality assurance tool, is discussed. MR and CT images of gel-water were acquired for visualisation and electron density verification. Characterisation of gel-water at 0 T was compared to Gammex-RMI solid water, using MagicPlate-512 (M512) and RMI Attix chamber; this included percentage depth dose, tissue-phantom ratio (TPR20/10), tissue-maximum ratio (TMR), profiles, output factors, and a gamma analysis to investigate field penumbral differences. MR images of a non-powered detector in gel-water demonstrated detector visualisation. The CT-determined gel-water electron density agreed with the calculated value of 1.01. Gel-water depth dose data demonstrated a maximum deviation of 0.7% from solid water for M512 and 2.4% for the Attix chamber, and by 2.1% for TPR20/10 and 1.0% for TMR. FWHM and output factor differences between materials were ≤0.3 and ≤1.4%. M512 data passed gamma analysis with 100% within 2%, 2 mm tolerance for multileaf collimator defined fields. Gel-water was shown to be tissue-equivalent for dosimetry and a feasible option to replace solid water.

Keywords: Dosimetry; Gel phantom; Image-guidance; MRI-linac; Silicon array detector.

MeSH terms

  • Dose-Response Relationship, Radiation
  • Electrons
  • Gels / chemistry*
  • Magnetic Resonance Imaging / methods*
  • Particle Accelerators*
  • Phantoms, Imaging
  • Radiometry*
  • Tomography, X-Ray Computed
  • Water / chemistry*

Substances

  • Gels
  • Water