Predictive models of six-minute walking distance in adults with sickle cell anemia: Implications for rehabilitation

Cirlene de Lima Marinho; Maria Christina Paixão Maioli; Andrea Ribeiro Soares; Ricardo Bedirian; Pedro Lopes de Melo; Fernando Silva Guimarães; Arthur de Sá Ferreira; Agnaldo José Lopes

doi:10.1016/j.jbmt.2016.02.005

Predictive models of six-minute walking distance in adults with sickle cell anemia: Implications for rehabilitation

J Bodyw Mov Ther. 2016 Oct;20(4):824-831. doi: 10.1016/j.jbmt.2016.02.005. Epub 2016 Feb 15.

Authors

Cirlene de Lima Marinho¹, Maria Christina Paixão Maioli², Andrea Ribeiro Soares², Ricardo Bedirian³, Pedro Lopes de Melo⁴, Fernando Silva Guimarães⁵, Arthur de Sá Ferreira⁵, Agnaldo José Lopes⁶

Affiliations

¹ Post-graduate Program in Clinical and Experimental Physiopathology, School of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
² Hematology Department, State University of Rio de Janeiro, Rio de Janeiro, Brazil; Post-graduate Program in Medical Sciences, School of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
³ Post-graduate Program in Medical Sciences, School of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
⁴ Post-graduate Program in Clinical and Experimental Physiopathology, School of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, Brazil; Post-graduate Program in Medical Sciences, School of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, Brazil; Biomedical Instrumentation Laboratory, Institute of Biology and Faculty of Engineering, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
⁵ Rehabilitation Sciences Post-graduate Program, Augusto Motta University Center, Rio de Janeiro, Brazil.
⁶ Post-graduate Program in Medical Sciences, School of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, Brazil; Rehabilitation Sciences Post-graduate Program, Augusto Motta University Center, Rio de Janeiro, Brazil. Electronic address: agnaldolopes.uerj@gmail.com.

PMID: 27814863
DOI: 10.1016/j.jbmt.2016.02.005

Abstract

Background: Sickle cell anemia (SCA) is characterized by a broad spectrum of abnormalities that affect most body organs and systems. To date, there is few data on the influence of these patients' clinical characteristics on the functional exercise capacity.

Aim: To investigate the effect of the clinical complications on the functional exercise capacity of adult SCA patients.

Method: Cross-sectional study, where 45 SCA patients underwent clinical evaluations, echocardiography, pulmonary function testing, and determination of six-minute walking distance (6MWD).

Results: A significant correlation (P < 0.001) was found between 6MWD and hemoglobin (Hb) level, tricuspid regurgitation velocity, forced vital capacity, acute chest syndrome, and diffusing capacity for carbon monoxide. The prediction model for 6MWD explained 67% of the 6MWD variability (P < 0.001).

Conclusions: Hemodynamics, cardiovascular function, pulmonary function, and episodes of acute lung injury seem to impact the 6MWD in adults with SCA.

Keywords: Exercise; Hemodynamic; Performance; Respiratory function tests; Sickle cell anemia.

MeSH terms

Adult
Anemia, Sickle Cell / physiopathology*
Cross-Sectional Studies
Electrocardiography
Exercise Test / methods
Exercise Tolerance / physiology*
Female
Hemodynamics / physiology
Hemoglobins / analysis
Humans
Male
Middle Aged
Physical Therapy Modalities
Reproducibility of Results
Respiratory Function Tests
Walking / physiology*

Substances

Hemoglobins