A new synthesis and preliminary evaluation of some analogues of mecamylamine - a compound with anti-addiction properties

David Mangan; Neasa McNabola; Emily H Clark; Isabel Bermudez; Susan Wonnacott; J Mike Southern

doi:10.1039/c6ob01974a

A new synthesis and preliminary evaluation of some analogues of mecamylamine - a compound with anti-addiction properties

Org Biomol Chem. 2016 Nov 22;14(46):10787-10798. doi: 10.1039/c6ob01974a.

Authors

David Mangan¹, Neasa McNabola¹, Emily H Clark², Isabel Bermudez³, Susan Wonnacott², J Mike Southern¹

Affiliations

¹ Trinity Biomedical Sciences Institute, School of Chemistry, The University of Dublin, Trinity College, Dublin 2, Ireland. southerj@tcd.ie.
² Department of Biology & Biochemistry, University of Bath, Bath BA2 7AY, UK.
³ School of Life Sciences, Oxford Brookes University, Oxford OX3 0BP, UK.

PMID: 27812593
DOI: 10.1039/c6ob01974a

Abstract

A new synthesis of mecamylamine - a known anti-hypertensive drug with anti-addictive properties is described. The new route allowed access to two novel analogues whose activity at two nicotinic acetylcholine receptor subtypes was assessed.

MeSH terms

Antihypertensive Agents / chemical synthesis*
Antihypertensive Agents / chemistry
Antihypertensive Agents / pharmacology*
Antihypertensive Agents / therapeutic use
Behavior, Addictive / drug therapy*
Chemistry Techniques, Synthetic
Mecamylamine / chemical synthesis*
Mecamylamine / chemistry
Mecamylamine / pharmacology*
Mecamylamine / therapeutic use
Methylation
Receptors, Nicotinic / metabolism

Substances

Antihypertensive Agents
Receptors, Nicotinic
Mecamylamine