Abstract
A new synthesis of mecamylamine - a known anti-hypertensive drug with anti-addictive properties is described. The new route allowed access to two novel analogues whose activity at two nicotinic acetylcholine receptor subtypes was assessed.
MeSH terms
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Antihypertensive Agents / chemical synthesis*
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Antihypertensive Agents / chemistry
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Antihypertensive Agents / pharmacology*
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Antihypertensive Agents / therapeutic use
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Behavior, Addictive / drug therapy*
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Chemistry Techniques, Synthetic
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Mecamylamine / chemical synthesis*
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Mecamylamine / chemistry
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Mecamylamine / pharmacology*
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Mecamylamine / therapeutic use
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Methylation
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Receptors, Nicotinic / metabolism
Substances
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Antihypertensive Agents
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Receptors, Nicotinic
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Mecamylamine