Host and clinical aspects in patients with benign migratory glossitis

Arch Oral Biol. 2017 Jan:73:259-268. doi: 10.1016/j.archoralbio.2016.10.027. Epub 2016 Oct 26.

Abstract

Objective: Investigate the association of clinical, cytological and genetic characteristics with benign migratory glossitis (BMG).

Study design: Sample consisted of 175 patients, 44 with BMG and 131 control patients. Clinical examination and DMFT index were assessed. Cytological evaluation determined cell morphology and morphometry. Genetic evaluation was performed by analysing IL6 polymorphisms by real-time PCR. Univariate and multivariate analyses were performed (p<0.05).

Results: There was a higher level of anxiety, DMFT score and a prevalence of fissured tongue in BMG group. A high mean nuclear/cytoplasmic area ratio was observed in patients with BMG. There was predominance of Papanicolaou class II I BMG group. IL6 allele G rs2069843 polymorphism was associated with BMG in the dominant model. In multivariate analysis, DMFT and anxiety scale remained associated with BMG.

Keywords: Benign migratory glossitis; Genetic polymorphism; IL-6; Pap smear.

MeSH terms

  • Adult
  • Alleles
  • Anxiety / genetics
  • Anxiety / pathology
  • Brazil / epidemiology
  • Female
  • Genetic Predisposition to Disease
  • Glossitis, Benign Migratory / epidemiology
  • Glossitis, Benign Migratory / genetics*
  • Glossitis, Benign Migratory / pathology*
  • Glossitis, Benign Migratory / psychology
  • Humans
  • Interleukin-6 / genetics
  • Linkage Disequilibrium
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide
  • Prevalence
  • Socioeconomic Factors
  • Tongue, Fissured / epidemiology
  • Tongue, Fissured / genetics

Substances

  • IL6 protein, human
  • Interleukin-6