To explore the correlation between hyperuricemia and renal damage in patients with lupus nephritis (LN). Methods: The data for clinical features, laboratory and renal pathological examination were collected from 177 renal biopsy-proven LN patients with or without hyperuricemia and were retrospectively analyzed to determine the correlation between serum uric acid and renal damage. Results: LN patients with hyperuricemia group had higher rate of hypertension and higher level of blood urea nitrogen and serum creatinine while lower estimated glomerular filtration rate (eGFR) and lower positive rate of anti-U1RNP antibody (P<0.05). In the LN patients with hyperuricemia group, renal pathological scores, including acitive index, chronic index and tubulointerstitial lesions, were higher than those in the LN patients without hyperuricemia group (P<0.05). The level of serum uric acid was positively correlated with serum creatinine, renal pathological classification and renal pathological scores while negatively correlated with eGFR (P<0.05). Conclusion: LN patients with hyperuricemia are associated with more serious renal damage. Hyperuricemia is an important predictor for poor prognosis in patients with LN.
目的：探讨狼疮性肾炎(lupus nephritis，LN)患者高尿酸血症与肾损伤的关系。方法：回顾性分析经肾病理活检证实的177例LN患者，比较正常尿酸组和高尿酸血症组患者的临床特点、实验室检查和肾病理的差别，分析血清尿酸水平与肾损伤相关指标的关系。结果：LN合并高尿酸血症组的高血压发生率、血清尿素氮及血清肌酐水平较正常尿酸组显著升高(P<0.01)，而估算的肾小球滤过率(estimated glomerular filtration rate，eGFR)、抗U1RNP抗体阳性率较正常尿酸组显著降低(P<0.01)；高尿酸血症组患者的肾病理损伤评分(活动性指数、慢性化指数、肾小管间质损伤指数)均明显高于正常尿酸组(P<0.05)；LN患者血清尿酸水平与血清肌酐、肾病理分型和肾病理损伤评分均呈正相关，与eGFR呈负相关(P<0.01)。结论：合并高尿酸血症的LN患者肾损伤较重，高尿酸血症是狼疮性肾炎患者预后不良的重要指标之一。.