Four New 2-(2-Phenylethyl)chromone Derivatives from Chinese Agarwood Produced via the Whole-Tree Agarwood-Inducing Technique

Molecules. 2016 Oct 27;21(11):1433. doi: 10.3390/molecules21111433.

Abstract

Four new 2-(2-phenylethyl)chromone derivatives (1-4) were isolated from the EtOH extract of Chinese agarwood produced via the whole-tree agarwood-inducing technique, coming from Aquilaria sinensis (Lour.) Spreng. (Thymelaeaceae). Their structures were elucidated by extensive spectroscopic methods, such as UV, IR, MS, 1D as well as 2D NMR. All of the isolates were then assessed for their anti-inflammatory activities on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7. Compound 1 exhibited significant inhibitory activity with an IC50 value of 4.6 μM.

Keywords: 2-(2-phenylethyl)chromone derivatives; Aquilaria sinensis; Chinese agarwood; anti-inflammatory; whole-tree agarwood-inducing technique.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents* / chemistry
  • Anti-Inflammatory Agents* / isolation & purification
  • Anti-Inflammatory Agents* / pharmacology
  • Chromones* / chemistry
  • Chromones* / isolation & purification
  • Chromones* / pharmacology
  • Lipopolysaccharides / toxicity*
  • Mice
  • Nitric Oxide / biosynthesis*
  • RAW 264.7 Cells
  • Thymelaeaceae / chemistry*

Substances

  • Anti-Inflammatory Agents
  • Chromones
  • Lipopolysaccharides
  • Nitric Oxide