[A retrospective case-control study of immunoglobulin G4-related disease combined with malignancy]

Y L Feng; D Wu; S Y Zhang; X Wu; H J Shu; A M Yang; J M Qian

doi:10.3760/cma.j.issn.0578-1426.2016.11.011

[A retrospective case-control study of immunoglobulin G₄-related disease combined with malignancy]

Zhonghua Nei Ke Za Zhi. 2016 Nov 1;55(11):869-871. doi: 10.3760/cma.j.issn.0578-1426.2016.11.011.

[Article in Chinese]

Authors

Y L Feng¹, D Wu, S Y Zhang, X Wu, H J Shu, A M Yang, J M Qian

Affiliation

¹ Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

PMID: 27801343
DOI: 10.3760/cma.j.issn.0578-1426.2016.11.011

Abstract

IgG₄-related disease (IgG₄-RD) has been proved to be associated with malignancy.The incidence and risk factors of malignancy development in IgG₄-RD were not clear. Nine IgG₄-RD patients with malignancies and 27 IgG₄-RD control cases were analyzed for risk factors and clinical features. The incidence of malignancy in IgG₄-RD was 3.3%, higher than age-controlled general population. Smoking history was significantly more common in patients with malignancies than in the control group (9/9 vs 16/27, P<0.05). A total of 6/9 malignancies occurred within the first year after the diagnosis of IgG₄-RD. Colorectal, biliary and thyroid cancers were the leading types. Smoking history is a risk factor for IgG₄-RD associated malignancy. Careful vigilance to monitor malignancy needs to be paid during follow-up.

MeSH terms

Autoimmune Diseases / complications*
Autoimmune Diseases / diagnosis*
Autoimmune Diseases / epidemiology
Case-Control Studies
Female
Humans
Immunoglobulin G / biosynthesis*
Incidence
Male
Neoplasms / diagnosis
Neoplasms / epidemiology*
Neoplasms / pathology
Retrospective Studies

Substances

Immunoglobulin G