The operant perspective of chronic pain emphasizes the important role of reinforcement contingencies in the maintenance of pain behaviors and the experience of pain. Patients' 'significant others' are viewed as primary reinforcing agents. The relationship between pain intensity, interference, and responses by significant others in maritally distressed, maritally satisfied, and unmarried samples of male and female pain patients and their significant others was examined in this study. Results revealed that only for married male patients significant other responses explained significant proportions of the variance in the impact of pain. Significant other responses failed to explain significant proportions of the variance for male patients living with non-married significant others. By way of contrast, for female patients pain impact and reinforcement variables were less highly associated in the married as compared to the unmarried patients. For both males and females, there were significantly higher correlations between significant other responses and pain impact levels for the maritally satisfied patients. These results provide qualified support for the operant formulation of the importance of reinforcement of pain behaviors by significant others, however, these responses appear to be dependent upon gender, marital status, and marital satisfaction. Thus, clinicians need to give greater attention to these variables when designing treatment plans.