Cytotoxic lanostanes from fruits of Garcinia wallichii Choisy (Guttiferae)

Bioorg Med Chem Lett. 2016 Dec 1;26(23):5773-5779. doi: 10.1016/j.bmcl.2016.10.045. Epub 2016 Oct 15.

Abstract

Five new lanostanes, wallichinanes A-E (1-5) together with a known lanostane derivative 6 were isolated from the cytotoxic hexanes extract of fruits of Garcinia wallichii Choisy (Guttiferae). The structures of the isolated compounds were established by analysis of spectroscopic data, X-ray diffraction technique as well as comparison with the literature data. The cytotoxicity of all isolated compounds against a panel of cultured cancer cell lines was evaluated. Compound 4 exhibited good cytotoxicity with ED50 values ranging from 3.91 to 7.63μM.

Keywords: Cytotoxicity; Garcinia wallichii; Guttiferae; Lanostane; Triterpene.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry*
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Cell Line, Tumor
  • Fruit / chemistry
  • Garcinia / chemistry*
  • Humans
  • Lanosterol / analogs & derivatives*
  • Lanosterol / chemistry
  • Lanosterol / isolation & purification
  • Lanosterol / pharmacology
  • Models, Molecular
  • Neoplasms / drug therapy
  • X-Ray Diffraction

Substances

  • Antineoplastic Agents, Phytogenic
  • wallichinane D
  • Lanosterol