Platelet-Rich Plasma

Peter I-Kung Wu; Robert Diaz; Joanne Borg-Stein

doi:10.1016/j.pmr.2016.06.002

Platelet-Rich Plasma

Phys Med Rehabil Clin N Am. 2016 Nov;27(4):825-853. doi: 10.1016/j.pmr.2016.06.002.

Authors

Peter I-Kung Wu¹, Robert Diaz², Joanne Borg-Stein³

Affiliations

¹ Department of Physical Medicine & Rehabilitation, Spaulding Rehabilitation Hospital, Harvard Medical School, 300 First Avenue, Charlestown, MA 02129, USA. Electronic address: iwu3@partners.org.
² Department of Physical Medicine & Rehabilitation, Spaulding Rehabilitation Hospital, Harvard Medical School, 300 First Avenue, Charlestown, MA 02129, USA.
³ Department of Physical Medicine & Rehabilitation, Newton-Wellesley Hospital Spine Center, Spaulding Rehabilitation Hospital, Harvard Medical School, 65 Walnut Street, Wellesley, MA 02481, USA.

PMID: 27788903
DOI: 10.1016/j.pmr.2016.06.002

Abstract

Platelet-rich plasma (PRP) is a growing and robust therapeutic option in musculoskeletal medicine. PRP is a preparation of autologous plasma enriched with a platelet concentration above that normally contained in whole blood. The rationale for use and therapeutic potential of a high concentration of platelets is based on their capacity to supply supraphysiologic amounts of essential growth factors to provide a regenerative stimulus that promotes repair in tissues with low healing potential. This article reviews the latest basic science on PRP, clinical evidence for its use in musculoskeletal medicine, limitations in current knowledge, and critical areas for future research.

Keywords: Healing; Injection; Musculoskeletal; Platelet-rich plasma; Regenerative; Rehabilitation; Sports.

Publication types

Review

MeSH terms

Humans
Intercellular Signaling Peptides and Proteins / physiology*
Musculoskeletal Diseases / therapy*
Platelet-Rich Plasma*

Substances

Intercellular Signaling Peptides and Proteins