[Analysis of high-risk HPV infection and cervical cytologic screening in HIV positive women]

Abstract

Objective: To analysis of high-risk HPV infection and cervical cytologic screening in HIV positive women, and to study the relationship between HIV infection and high-risk HPV infection. Methods: From June 2011 to May 2016, 58 cases of HIV positive women in Beijing Ditan Hospital for cervical screening were selected as the experimental group, and 59 cases of HIV negative women were selected as control group, thin-prep cytologic test(TCT)and HPV detection were used in two groups of subjects. The abnormal rate of TCT and the incidence rate of HPV were observed in the two groups, the relationship between HIV infection and HPV infection was analyzed. Results: TCT abnormal rate(91.4%, 53/58)of the experimental group was obviously higher than that of the control group(45.8%, 27/59), with statistically significant(χ²=12.365, P=0.036). High-risk HPV infection incidence(34.5%, 20/58)of the experimental group was significantly higher than that of the control group(16.9%, 10/59), with traditional significance(χ²=10.359, P=0.041). CD₄⁺ T lymphocytes and CD₄⁺/CD₈⁺ ratio of high-risk HPV positive patients had significant difference with high-risk HPV negative patients(χ²=10.378, P=0.042; χ²=9.245, P=0.045). The proportion of different AIDS clinical stages of high-risk HPV positive patients had obvious difference with high-risk HPV negative patients(P<0.05). Conclusion: HIV positive women maybe have a large proportion of abnormal TCT and the infection with high-risk HPV, and infection of high-risk HPV in HIV positive women has relationship with CD₄⁺ T lymphocytes, CD₄⁺/CD₈⁺ ratio and AIDS clinical stage.