The prognostic value of MR-proadrenomedullin in patients with acute coronary syndrome complicated by cardiogenic shock

Biomarkers. 2017 May-Jun;22(3-4):296-303. doi: 10.1080/1354750X.2016.1252962. Epub 2016 Nov 9.

Abstract

Context: Cardiogenic shock (CS) still remains one of the main causes of death in acute myocardial infarction (AMI).

Objective: The aim of this study was to evaluate the prognostic value of midregional (MR)-proadrenomedullin in AMI complicated by CS.

Methods: Forty-seven consecutive patients were included in our prospective observational study. All patients underwent coronarography and successful percutaneous coronary intervention (PCI). Plasma levels of MR-proADM were measured by a immunofluorescence method. The primary endpoint of the study, defined as cardiovascular death, occurred in 17 patients (36%).

Results and conclusion: Elevated plasma level of MR-proADM, determined 24 h after diagnosis of CS could be a predictor of in-hospital mortality in patients with AMI complicated by CS.

Keywords: Cardiogenic shock; MR-proadrenomedullin; myocardial infarction.

Publication types

  • Observational Study

MeSH terms

  • Acute Coronary Syndrome / complications*
  • Adrenomedullin / blood*
  • Adult
  • Aged
  • Aged, 80 and over
  • Hospital Mortality
  • Humans
  • Middle Aged
  • Myocardial Infarction / complications
  • Prognosis
  • Prospective Studies
  • Protein Precursors / blood*
  • Shock, Cardiogenic / complications*

Substances

  • Protein Precursors
  • proadrenomedullin
  • Adrenomedullin