Effect of Combination of Non-Invasive Spinal Cord Electrical Stimulation and Serotonin Receptor Activation in Patients with Chronic Spinal Cord Lesion

Bull Exp Biol Med. 2016 Oct;161(6):749-754. doi: 10.1007/s10517-016-3501-4. Epub 2016 Oct 26.

Abstract

We analyzed the efficiency of percutaneous electrical stimulation of the spinal cord and serotonin receptor activation in rehabilitation of paralyzed patients. Four-week course of spinal cord electrical stimulation combined with mechanotherapy produced positive shifts in the status of chronically paralyzed patients. Serotonin receptor activation potentiated the effect of spinal cord stimulation and can be regarded as an additional neurorehabilitation option.

Keywords: buspirone; complete and incomplete plegia; electric stimulation of the spinal cord; neurological performance.

MeSH terms

  • Adult
  • Aged
  • Buspirone / therapeutic use*
  • Combined Modality Therapy
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nociception / drug effects
  • Nociception / physiology
  • Receptors, Serotonin / metabolism*
  • Serotonin Receptor Agonists / therapeutic use*
  • Spinal Cord / drug effects
  • Spinal Cord / metabolism
  • Spinal Cord / pathology
  • Spinal Cord Injuries / metabolism
  • Spinal Cord Injuries / pathology
  • Spinal Cord Injuries / therapy*
  • Spinal Cord Stimulation / methods*
  • Touch Perception / drug effects
  • Touch Perception / physiology
  • Treatment Outcome

Substances

  • Receptors, Serotonin
  • Serotonin Receptor Agonists
  • Buspirone