Dimeric furanocoumarins from the roots of Angelica dahurica

Nat Prod Res. 2017 Apr;31(8):870-877. doi: 10.1080/14786419.2016.1250090. Epub 2016 Oct 27.

Abstract

Three new dimeric furanocoumarins, dahuribiethrins H-J (1-3), and a new ester coumarin, dahurinol A (4), were isolated from the roots of Angelica dahurica. Their structures were elucidated on the basis of extensive spectroscopic data including UV, IR, HRESIMS, 1D and 2D NMR. Compounds 2 and 3 exhibited inhibition of nitric oxide production in the lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells with IC50 values of 8.7 ± 0.6 and 27.3 ± 0.9 μM, respectively.

Keywords: Angelica dahurica; anti-inflammatory; coumarin; dimeric furanocoumarin; nitric oxide production.

MeSH terms

  • Angelica / chemistry*
  • Animals
  • Drug Evaluation, Preclinical / methods
  • Furocoumarins / chemistry*
  • Furocoumarins / isolation & purification
  • Furocoumarins / pharmacology*
  • Inhibitory Concentration 50
  • Lipopolysaccharides / pharmacology
  • Magnetic Resonance Spectroscopy
  • Mice
  • Molecular Structure
  • Nitric Oxide / metabolism
  • Plant Roots / chemistry
  • Plants, Medicinal / chemistry
  • RAW 264.7 Cells / drug effects

Substances

  • Furocoumarins
  • Lipopolysaccharides
  • dahuribiethrin H
  • dahurinol A
  • Nitric Oxide