Amide of Lambertian Acid Suppresses Hyperactivation of Inotropic Glutamate Receptors, but not Synaptic Potentiation in Hippocampal Sections

S O Vechkapova; T A Zapara; E A Morozova; A L Proskura; E E Schul'ts; T G Tolstikova; A S Ratushnyak

doi:10.1007/s10517-016-3509-9

Amide of Lambertian Acid Suppresses Hyperactivation of Inotropic Glutamate Receptors, but not Synaptic Potentiation in Hippocampal Sections

Bull Exp Biol Med. 2016 Oct;161(6):782-785. doi: 10.1007/s10517-016-3509-9. Epub 2016 Oct 26.

Authors

S O Vechkapova¹, T A Zapara², E A Morozova³, A L Proskura², E E Schul'ts³, T G Tolstikova³, A S Ratushnyak²

Affiliations

¹ Design Technological Institute of Digital Techniques, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia. svetavech@yandex.ru.
² Design Technological Institute of Digital Techniques, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
³ N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.

PMID: 27783303
DOI: 10.1007/s10517-016-3509-9

Abstract

Amide of lambertian acid suppresses hyperactivation of inotropic glutamate receptors in hippocampal sections induced by a decrease in the level of magnesium ions (a selective blocker of glutamate NMDA receptors). Treatment of the sections with amide of lambertian acid in standard physiological saline does not prevent development of NMDA-dependent synaptic potentiation. Lambertian acid isolated from needles and turpentine of Siberian pine (Pinus sibirica R. Mayr), and its derivatives may become a source of substances with glutamatergic mechanism of action for treatment of cognitive and neurodegenerative disorders.

Keywords: amide of lambertian acid; hippocampal sections; hyperactivation of glutamatergic receptors; post-tetanic synaptic potentiation.

MeSH terms

Amides / chemistry
Animals
CA1 Region, Hippocampal / cytology
CA1 Region, Hippocampal / drug effects
CA1 Region, Hippocampal / physiology
Carboxylic Acids / isolation & purification
Carboxylic Acids / pharmacology*
Excitatory Amino Acid Antagonists / pharmacology
Long-Term Potentiation / physiology
Magnesium / pharmacology
Male
Mice
Mice, Inbred ICR
Microtomy
Naphthalenes / isolation & purification
Naphthalenes / pharmacology*
Neurons / cytology
Neurons / drug effects*
Neurons / physiology
Neuroprotective Agents / isolation & purification
Neuroprotective Agents / pharmacology*
Pinus / chemistry
Receptors, Ionotropic Glutamate / antagonists & inhibitors*
Receptors, Ionotropic Glutamate / metabolism
Synapses / physiology
Tissue Culture Techniques

Substances

Amides
Carboxylic Acids
Excitatory Amino Acid Antagonists
Naphthalenes
Neuroprotective Agents
Receptors, Ionotropic Glutamate
lambertianic acid
Magnesium