Dipeptidyl Peptidase-4, Wound Healing, Scarring, and Fibrosis

Plast Reconstr Surg. 2016 Nov;138(5):1026-1031. doi: 10.1097/PRS.0000000000002634.

Abstract

Scarring and fibrosis are an enormous public health concern, resulting in excessive morbidity and mortality in addition to countless lost health care dollars. Recent advances in cell and developmental biology promise a better understanding of scarring and fibrosis and may translate to new clinical therapies.

Publication types

  • Review

MeSH terms

  • Animals
  • Cardiomyopathies / enzymology
  • Cardiomyopathies / pathology
  • Cicatrix / physiopathology*
  • Cicatrix / prevention & control
  • Connective Tissue / metabolism
  • Dipeptidyl Peptidase 4 / physiology*
  • Dipeptidyl-Peptidase IV Inhibitors / pharmacology
  • Dipeptidyl-Peptidase IV Inhibitors / therapeutic use*
  • Fibroblasts / enzymology
  • Fibroblasts / pathology*
  • Fibrosis / enzymology
  • Fibrosis / prevention & control
  • Homeodomain Proteins / genetics
  • Homeodomain Proteins / physiology
  • Humans
  • Hypoglycemic Agents / pharmacology
  • Hypoglycemic Agents / therapeutic use
  • Inflammation / physiopathology
  • Inflammation / prevention & control
  • Kidney Diseases / enzymology
  • Kidney Diseases / pathology
  • Liver Cirrhosis / enzymology
  • Liver Cirrhosis / pathology
  • Mice
  • Mice, Transgenic
  • Wound Healing / drug effects
  • Wound Healing / physiology*

Substances

  • Dipeptidyl-Peptidase IV Inhibitors
  • En1 protein, mouse
  • Homeodomain Proteins
  • Hypoglycemic Agents
  • DPP4 protein, human
  • Dipeptidyl Peptidase 4