Water Soluble Melanin Derivatives for Dynamic Contrast Enhanced Photoacoustic Imaging of Tumor Vasculature and Response to Antiangiogenic Therapy

Dario L Longo; Rachele Stefania; Chiara Callari; Francesco De Rose; Riccardo Rolle; Laura Conti; Lorena Consolino; Francesca Arena; Silvio Aime

doi:10.1002/adhm.201600550

Water Soluble Melanin Derivatives for Dynamic Contrast Enhanced Photoacoustic Imaging of Tumor Vasculature and Response to Antiangiogenic Therapy

Adv Healthc Mater. 2017 Jan;6(1). doi: 10.1002/adhm.201600550. Epub 2016 Oct 26.

Authors

Dario L Longo¹, Rachele Stefania², Chiara Callari², Francesco De Rose², Riccardo Rolle², Laura Conti², Lorena Consolino², Francesca Arena², Silvio Aime²

Affiliations

¹ Institute of Biostructure and Bioimaging (CNR) c/o Molecular Biotechnology Center, Via Nizza 52, 10126, Torino, Italy.
² Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, 10126, Torino, Italy.

PMID: 27782375
DOI: 10.1002/adhm.201600550

Abstract

A dynamic contrast enhanced (DCE) approach for tumor photoacoustic (PA) imaging is described. Novel water soluble melanin-based derivatives are synthesized that exhibit good PA properties, stability, safety and accumulation in tumor bearing mice. This melanin derivative is capable to characterize tumor vasculature and to monitor vessel permeability changes upon antiangiogenic treatment. DCE-PA imaging can assess functional response to cancer treatments.

Keywords: dynamic contrast enhanced; melanin; nanoparticles; photoacoustic; tumors.

MeSH terms

Animals
Diagnostic Imaging / methods*
Female
Mammary Neoplasms, Experimental / diagnostic imaging*
Melanins / chemistry
Melanins / pharmacology*
Mice
Neovascularization, Pathologic / diagnostic imaging*
Photoacoustic Techniques / methods*

Substances

Melanins