Insulin as a weapon

Toxicon. 2016 Dec 1:123:56-61. doi: 10.1016/j.toxicon.2016.10.010. Epub 2016 Oct 21.

Abstract

The discovery of insulin and its use for the treatment of diabetes is undoubtedly one of the true successes of modern medicine. Injectable insulin would prove the first effective treatment for a previously incurable and usually fatal disease. Soon after however, the powerful effects of insulin overdose would be reported, and subsequently exploited for dubious medical and sometimes nefarious purposes. In this article we describe the discovery that certain venomous marine snails of the genus Conus also exploit the powerful effects of insulin overdose, employing it as a weapon for prey capture.

Keywords: Hypoglycemic shock; Insulin; Insulin shock; Predation; Venom.

Publication types

  • Review

MeSH terms

  • Animals
  • Conus Snail / genetics
  • Conus Snail / physiology*
  • Insulin / chemistry
  • Insulin / toxicity*
  • Mollusk Venoms / chemistry
  • Mollusk Venoms / toxicity*
  • Phylogeny
  • Sequence Alignment
  • Sequence Analysis, Protein

Substances

  • Insulin
  • Mollusk Venoms