Fat body remodeling and homeostasis control in Drosophila

Huimei Zheng; Xiaohang Yang; Yongmei Xi

doi:10.1016/j.lfs.2016.10.019

Fat body remodeling and homeostasis control in Drosophila

Life Sci. 2016 Dec 15:167:22-31. doi: 10.1016/j.lfs.2016.10.019. Epub 2016 Oct 20.

Authors

Huimei Zheng¹, Xiaohang Yang², Yongmei Xi³

Affiliations

¹ Division of Human Reproduction and Developmental Genetics, the Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Institute of Genetics, Zhejiang University and Department of Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China; College of Life Sciences, Zhejiang University, Hangzhou, China.
² Division of Human Reproduction and Developmental Genetics, the Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Institute of Genetics, Zhejiang University and Department of Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China; Joint Institute of Genetics and Genomic Medicine between Zhejiang University and University of Toronto, Zhejiang University, Hangzhou, Zhejiang, China.
³ Division of Human Reproduction and Developmental Genetics, the Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Institute of Genetics, Zhejiang University and Department of Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China. Electronic address: xyyongm@zju.edu.cnc.

PMID: 27773719
DOI: 10.1016/j.lfs.2016.10.019

Abstract

Remarkable advances have been made in recent years in our understanding of the Drosophila fat body and its functions in energy storage, immune response and nutrient sensing. The fat body interplays with other tissues to respond to the physiological needs of the body's growth and coordinates various metabolic processes at different developmental stages and under different environmental conditions. The identification of various conserved genetic functions and signaling pathways relating to the Drosophila fat body may provide clues to lipometabolic disease and other aspects of tissue remodeling in humans. Here, we discuss recent insights into how regulation of fat body remodeling contributes to hemostasis with a special focus on how signaling networks and internal physiological states shape different aspects of the lipid metabolism in Drosophila.

Keywords: Drosophila; Energy storage; Fat body remodeling; Fat mobilization; Lipometabolism.

Publication types

Review

MeSH terms

Animals
Drosophila / anatomy & histology
Drosophila / physiology*
Energy Metabolism
Fat Body / anatomy & histology
Fat Body / physiology*
Homeostasis*
Lipid Metabolism*
Longevity
Signal Transduction