RNA Structure Switches RBP Binding

Zheng Luo; Qin Yang; Li Yang

doi:10.1016/j.molcel.2016.10.006

RNA Structure Switches RBP Binding

Mol Cell. 2016 Oct 20;64(2):219-220. doi: 10.1016/j.molcel.2016.10.006.

Authors

Zheng Luo¹, Qin Yang¹, Li Yang²

Affiliations

¹ Key Laboratory of Computational Biology, CAS Center for Excellence in Brain Science and Intelligence Technology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; University of Chinese Academy of Sciences, Beijing 100049, China.
² Key Laboratory of Computational Biology, CAS Center for Excellence in Brain Science and Intelligence Technology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; University of Chinese Academy of Sciences, Beijing 100049, China; School of Life Science and Technology, ShanghaiTech University, Shanghai 200031, China. Electronic address: liyang@picb.ac.cn.

PMID: 27768870
DOI: 10.1016/j.molcel.2016.10.006

Abstract

RNA sequence motifs are not sufficient for association with RBPs. In this issue of Molecular Cell, Taliaferro et al. (2016) demonstrate that, other than sequence motif, RNA secondary structure plays a repressive role on RBP binding, both in vitro and in vivo.

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MeSH terms

Nucleotide Motifs
RNA / chemistry*
RNA-Binding Proteins / chemistry*

Substances

RNA-Binding Proteins
RNA