ESBL-Producing and Macrolide-Resistant Shigella sonnei Infections among Men Who Have Sex with Men, England, 2015

Emerg Infect Dis. 2016 Nov;22(11):1948-1952. doi: 10.3201/eid2211.160653.

Abstract

In England in 2015, Shigella sonnei isolates from men who have sex with men produced extended-spectrum β-lactamases and exhibited macrolide resistance. Whole-genome sequencing showed a close relationship among the isolates, which harbored a plasmid that was previously identified in a shigellosis outbreak among this population but has acquired a mobile element.

Keywords: ESBL; ESBL producers; England; MSM; STIs; Shigella; Shigella sonnei; antimicrobial resistance; bacteria; bacterial infections; extended-spectrum beta-lactamase; men who have sex with men; outbreaks; sexually transmitted infections.

Publication types

  • Historical Article

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Drug Resistance, Bacterial*
  • Dysentery, Bacillary / drug therapy
  • Dysentery, Bacillary / epidemiology*
  • Dysentery, Bacillary / history
  • Dysentery, Bacillary / microbiology*
  • England / epidemiology
  • Genome, Bacterial
  • History, 21st Century
  • Homosexuality, Male*
  • Humans
  • Macrolides / pharmacology*
  • Male
  • Microbial Sensitivity Tests
  • Phylogeny
  • Polymorphism, Single Nucleotide
  • Shigella sonnei / classification
  • Shigella sonnei / drug effects*
  • Shigella sonnei / genetics*
  • Whole Genome Sequencing
  • beta-Lactamases / biosynthesis
  • beta-Lactamases / genetics*

Substances

  • Anti-Bacterial Agents
  • Macrolides
  • beta-Lactamases