Class II-Restricted CD8s: New Lessons Violate Old Paradigms

Stephen A Migueles; Mark Connors

doi:10.1016/j.immuni.2016.10.004

Class II-Restricted CD8s: New Lessons Violate Old Paradigms

Immunity. 2016 Oct 18;45(4):712-714. doi: 10.1016/j.immuni.2016.10.004.

Authors

Stephen A Migueles¹, Mark Connors²

Affiliations

¹ HIV-Specific Immunity Section, Laboratory of Immunoregulation, Division of Intramural Research NIAID, Bethesda, MD 20892, USA.
² HIV-Specific Immunity Section, Laboratory of Immunoregulation, Division of Intramural Research NIAID, Bethesda, MD 20892, USA. Electronic address: mconnors@nih.gov.

Abstract

CD8⁺ T cells that recognize peptides presented by MHC class II molecules have been observed in a macaque SIV vaccine model. A new study by Ranasinghe et al. (2016) shows that virus-specific class-II-restricted CD8⁺ T cells can be found in some HIV-infected patients.

Published by Elsevier Inc.

Publication types

Review
Comment

MeSH terms

Animals
CD8-Positive T-Lymphocytes / immunology*
Histocompatibility Antigens Class II / immunology*
Humans
SAIDS Vaccines / immunology
Simian Acquired Immunodeficiency Syndrome / immunology
Simian Immunodeficiency Virus / immunology

Substances

Histocompatibility Antigens Class II
SAIDS Vaccines

Abstract

Publication types

MeSH terms

Substances

Grants and funding