Development of an electrochemical 188W/188Re generator as a technique for separation and purification of 188Re in radiopharmaceutical applications

Abstract

In this study, a simple electrochemical procedure adaptable for using low specific activity ¹⁸⁸W for separation and purification of ¹⁸⁸Re from ¹⁸⁸W to obtain no carrier added (NCA) ¹⁸⁸Re is developed. The electrochemical parameters were optimized to maximize the ¹⁸⁸Re electrodeposition yield with minimal ¹⁸⁸W contamination. Two cycle electrolysis procedure was developed. The first electrochemical cell was used for separation of ¹⁸⁸Re and in the second electrochemical cell, separation and purification of ¹⁸⁸Re with >90% deposition yield of ¹⁸⁸Re and minimal contamination of ¹⁸⁸W (<10^-4%) was achieved. The overall electrodeposition yield of ¹⁸⁸Re was >90% with >99% radionuclidic purity and >99% radiochemical purity suitable for radiopharmaceutical applications. Furthermore, the performance of the generator remained consistent during a period of 69 days, one half-life of ¹⁸⁸W, when the electrochemical separation procedure was performed frequently, at least once in 5 days.

Keywords: (188)W/(188)Re generator; Electrodeposition yield; Radiochemical purity; Radionuclidic purity; Separation.