Efficacy of palliative radiation therapy for symptomatic rectal cancer

David Chia; Jiade Lu; HuiLi Zheng; EnYun Loy; Keith Lim; ChengNang Leong; LeaChoung Wong; Gabriel Tan; Desiree Chen; Francis Ho; Jeremy Tey

doi:10.1016/j.radonc.2016.06.023

Efficacy of palliative radiation therapy for symptomatic rectal cancer

Radiother Oncol. 2016 Nov;121(2):258-261. doi: 10.1016/j.radonc.2016.06.023. Epub 2016 Oct 13.

Authors

Affiliations

¹ Department of Radiation Oncology, National University Hospital, National Cancer Institute of Singapore, Singapore; Department of Radiation Oncology, Tan Tock Seng Hospital, National Cancer Institute of Singapore, Singapore.
² National Registry of Diseases Office, Health Promotion Board, Singapore.
³ Department of Radiation Oncology, National University Hospital, National Cancer Institute of Singapore, Singapore.

PMID: 27745911
DOI: 10.1016/j.radonc.2016.06.023

Abstract

99 patients with symptomatic locally advanced rectal cancer who were treated with palliative radiation alone were reviewed. Dose-fractionation ranged from 18 to 54Gy. Response rate ranged from 62.5 to 86.7%, with a median response duration ranging 4.2-5.4months. Median survival was 6.9months. Using a BED cut-off of 39Gy_10, no dose-response relationship was found.

Keywords: Bleeding; Cancer; Pain; Palliative; Radiotherapy; Rectum.

MeSH terms

Adult
Aged
Aged, 80 and over
Dose Fractionation, Radiation
Female
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Neoplasm Recurrence, Local / radiotherapy
Pain Management / methods
Palliative Care / methods*
Radiotherapy Dosage
Radiotherapy, Conformal / adverse effects
Radiotherapy, Conformal / methods
Rectal Neoplasms / radiotherapy*
Retrospective Studies