Validation of Effective Therapeutic Targets for ADPKD Using Animal Models

Yu Mi Woo; Je Yeong Ko; Eun Ji Lee

doi:10.1007/978-981-10-2041-4_7

Validation of Effective Therapeutic Targets for ADPKD Using Animal Models

Adv Exp Med Biol. 2016:933:71-84. doi: 10.1007/978-981-10-2041-4_7.

Authors

Yu Mi Woo¹, Je Yeong Ko², Eun Ji Lee²

Affiliations

¹ Molecular Medicine Laboratory, Department of Life systems, Sookmyung Women's University, Cheongpa-ro 47-gil 100, Yongsan-gu, Seoul, 04310, South Korea. milkmi@sm.ac.kr.
² Molecular Medicine Laboratory, Department of Life systems, Sookmyung Women's University, Cheongpa-ro 47-gil 100, Yongsan-gu, Seoul, 04310, South Korea.

PMID: 27730436
DOI: 10.1007/978-981-10-2041-4_7

Abstract

Various polycystic kidney disease (PKD) animal models including Pkd1- or Pkd2-deficient mice have been developed and efficiently utilized to identify novel therapeutic targets as well as elucidate multiple mechanisms of cyst formation in PKD. Based on several successful in vivo studies, preclinical approaches using PKD animal models would shed light on the development of potential therapeutic strategies for PKD. Here, we provide an update on the current evidence obtained by the in vivo evaluation of PKD therapeutic candidates and discuss the effect of therapeutic targets.

Keywords: Animal model; PKD; Therapeutic target.

Publication types

Review

MeSH terms

Animals
Disease Models, Animal
Humans
Molecular Targeted Therapy / methods*
Polycystic Kidney, Autosomal Dominant / drug therapy*
Polycystic Kidney, Autosomal Dominant / genetics