Biological Functions and Clinical Applications of Anti-Müllerian Hormone in Stallions and Mares

Vet Clin North Am Equine Pract. 2016 Dec;32(3):451-464. doi: 10.1016/j.cveq.2016.07.004. Epub 2016 Oct 8.

Abstract

Anti-Müllerian hormone (AMH) plays a major role in sexual differentiation, Leydig cell differentiation, and folliculogenesis. In addition, AMH has clinical value in equine practice. In stallions, AMH can serve as an endocrine marker for equine cryptorchidism and as an immunohistochemical marker for Sertoli cell tumors. Considering that AMH is also an ovarian specific product, intact mares can be differentiated from ovariectomized mares. Peripheral AMH concentrations reflect the follicular population in mares, and therefore, are useful in the assessment of ovarian reserve and reproductive life-span of aged mares. Last, AMH is particularly suitable as a diagnostic marker for equine granulosa cell tumors.

Keywords: Anti-Müllerian hormone; Cryptorchidism; Equine; Equine granulosa cell tumor; Mare; Ovarian reserve; Sertoli cell tumor; Stallion.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Mullerian Hormone / blood
  • Anti-Mullerian Hormone / metabolism*
  • Biomarkers / blood
  • Estrous Cycle / physiology
  • Female
  • Horse Diseases / blood
  • Horses / physiology*
  • Male
  • Ovarian Follicle / physiology

Substances

  • Biomarkers
  • Anti-Mullerian Hormone