Caging the uncageable: using metal complex release for photochemical control over irreversible inhibition

Matthew Huisman; Jessica K White; Veronica G Lewalski; Izabela Podgorski; Claudia Turro; Jeremy J Kodanko

doi:10.1039/c6cc07083c

Caging the uncageable: using metal complex release for photochemical control over irreversible inhibition

Chem Commun (Camb). 2016 Oct 18;52(85):12590-12593. doi: 10.1039/c6cc07083c.

Authors

Matthew Huisman¹, Jessica K White², Veronica G Lewalski¹, Izabela Podgorski³, Claudia Turro², Jeremy J Kodanko⁴

Affiliations

¹ Department of Chemistry, Wayne State University, Detroit, MI 48202, USA. jkodanko@chem.wayne.edu.
² Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA. turro1@osu.edu.
³ Department of Pharmacology, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA and Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA.
⁴ Department of Chemistry, Wayne State University, Detroit, MI 48202, USA. jkodanko@chem.wayne.edu and Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA.

Abstract

Photochemical control over irreversible inhibition was shown using Ru(ii)-caged inhibitors of cathepsin L. Levels of control were dependent on where the Ru(ii) complex was attached to the organic inhibitor, reaching >10 : 1 with optimal placement. A new strategy for photoreleasing Ru(ii) fragments from inhibitor-enzyme conjugates is also reported.

Grants and funding

R01 EB016072/EB/NIBIB NIH HHS/United States