More Challenges From Ebola: Infection of the Central Nervous System

Gary Wong; Xiangguo Qiu; Yuhai Bi; Pierre Formenty; Armand Sprecher; Michael Jacobs; George F Gao; Gary Kobinger

doi:10.1093/infdis/jiw257

More Challenges From Ebola: Infection of the Central Nervous System

J Infect Dis. 2016 Oct 15;214(suppl 3):S294-S296. doi: 10.1093/infdis/jiw257.

Authors

Gary Wong¹, Xiangguo Qiu², Yuhai Bi³, Pierre Formenty⁴, Armand Sprecher⁵, Michael Jacobs⁶, George F Gao⁷, Gary Kobinger⁸

Affiliations

¹ CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada Department of Medical Microbiology.
² Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada Department of Medical Microbiology.
³ CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People's Hospital, China.
⁴ Department of Pandemic and Epidemic Diseases, World Health Organization, Geneva, Switzerland.
⁵ Médecins Sans Frontières, Operational Center of Brussels, Belgium.
⁶ Department of Infection, Royal Free London NHS Foundation Trust, London, United Kingdom.
⁷ CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences Office of the Director General, Chinese Center for Disease Control and Prevention, Beijing Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People's Hospital, China.
⁸ Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada Department of Medical Microbiology Department of Immunology, University of Manitoba, Winnipeg, Canada Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia.

Abstract

Cases of relapsed Ebola virus disease involving symptoms in the central nervous system are reminiscent of our past observations with some nonhuman primates (NHPs) that survived acute Ebola virus infection. We document our findings in detail here and suggest that this phenomenon can be further investigated in NHPs.

Keywords: Ebola virus; central nervous system; nonhuman primates; relapse; outbreak.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Central Nervous System / virology*
Ebolavirus / pathogenicity*
Hemorrhagic Fever, Ebola / virology*
Humans
Recurrence

Abstract

Publication types

MeSH terms

Grants and funding