Tamoxifen metabolism in breast cancer treatment: Taking the focus off the CYP2D6 gene

Pharmacogenomics J. 2017 Mar;17(2):109-111. doi: 10.1038/tpj.2016.73. Epub 2016 Oct 4.

Authors

A Novillo¹, A Romero-Lorca¹, M Gaibar¹, M Rubio¹, A Fernández-Santander¹

Affiliation

¹ Department of Basic Biomedical Sciences, Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid, Madrid, Spain.

PMID: 27698402
DOI: 10.1038/tpj.2016.73

No abstract available

MeSH terms

Adult
Aged
Antineoplastic Agents, Hormonal / administration & dosage*
Antineoplastic Agents, Hormonal / blood
Antineoplastic Agents, Hormonal / pharmacokinetics
Breast Neoplasms / blood
Breast Neoplasms / drug therapy*
Breast Neoplasms / genetics
Breast Neoplasms / pathology
Cytochrome P-450 CYP2D6 / genetics*
Female
Genotype
Humans
Middle Aged
Pharmacogenetics
Tamoxifen / administration & dosage*
Tamoxifen / blood
Tamoxifen / pharmacokinetics

Substances

Antineoplastic Agents, Hormonal
Tamoxifen
Cytochrome P-450 CYP2D6