A single session of exhaustive exercise markedly decreases circulating levels of guanidinoacetic acid in healthy men and women

Valdemar Stajer; Tatjana Trivic; Patrik Drid; Milan Vranes; Sergej M Ostojic

doi:10.1139/apnm-2016-0102

A single session of exhaustive exercise markedly decreases circulating levels of guanidinoacetic acid in healthy men and women

Appl Physiol Nutr Metab. 2016 Oct;41(10):1100-1103. doi: 10.1139/apnm-2016-0102. Epub 2016 Jul 19.

Authors

Valdemar Stajer¹, Tatjana Trivic¹, Patrik Drid¹, Milan Vranes², Sergej M Ostojic^{1

3}

Affiliations

¹ a Applied Bioenergetics Lab, Biomedical Sciences Department, Faculty of Sport and Physical Education, University of Novi Sad, Lovcenska 16, Novi Sad 21000, Serbia.
² b Faculty of Sciences, University of Novi Sad, Novi Sad 21000, Serbia.
³ c University of Belgrade School of Medicine, Belgrade, Belgrade 11000, Serbia.

PMID: 27690568
DOI: 10.1139/apnm-2016-0102

Abstract

We evaluated the effects of exercise on circulating concentrations of guanidinoacetic acid (GAA) and creatine in 23 healthy volunteers subjected to running to exhaustion and free-weight bench-press to volitional failure. Blood was taken before and following each exercise session. Running induced a significant decrease in serum GAA by 20.1% (P < 0.001), while free-weight exercise reduced GAA by 11.7% (P < 0.001), suggesting the possible use of serum GAA as a novel biomarker of exhaustion.

Keywords: bench press; bioenergetics; bioénergétique; courir jusqu’à épuisement; creatine; creatinine; créatine; créatinine; développé au banc; running-to-exhaustion.