S100A8/A9 in psoriatic plaques from patients with psoriatic arthritis

Maria Sole Chimenti; Paola Triggianese; Elisabetta Botti; Alessandra Narcisi; Paola Conigliaro; Alessandro Giunta; Miriam Teoli; Roberto Perricone; Antonio Costanzo

doi:10.1177/0300060515598900

S100A8/A9 in psoriatic plaques from patients with psoriatic arthritis

J Int Med Res. 2016 Sep;44(1 suppl):33-37. doi: 10.1177/0300060515598900.

Authors

Maria Sole Chimenti¹, Paola Triggianese², Elisabetta Botti³, Alessandra Narcisi³, Paola Conigliaro², Alessandro Giunta⁴, Miriam Teoli⁴, Roberto Perricone², Antonio Costanzo³

Affiliations

¹ Rheumatology, Allergology and Clinical Immunology, Department of Systemic Medicine, University of Rome "Tor Vergata", Rome, Italy maria.sole.chimenti@uniroma2.it.
² Rheumatology, Allergology and Clinical Immunology, Department of Systemic Medicine, University of Rome "Tor Vergata", Rome, Italy.
³ Dermatology, Department of Neurosciences, Mental Health and Sensory (NESMOS), University of Rome "La Sapienza", Rome, Italy.
⁴ Dermatology, Department of Systemic Medicine, University of Rome "Tor Vergata", Rome, Italy.

Abstract

Objective: To evaluate levels of the calcium-binding proteins S100A8 and S100A9 in the skin of patients with psoriatic arthritis.

Methods: Skin punch biopsies were obtained from patients with psoriatic arthritis and healthy control subjects. S100A8/A9 were semiquantified via immunohistochemistry and semiquantitative polymerase chain reaction.

Results: The study included biopsies from nine patients with psoriatic arthritis and nine control subjects. S100A8 and S100A9 were present at visibly higher levels in psoriatic plaques compared with normal skin samples. S100A8 and S100A9 RNA levels were significantly higher in the peripheral region of plaques compared with the central region.

Conclusion: Both S100A8 and S100A9 may represent good therapeutic targets in psoriasis and psoriatic arthritis.

Keywords: Inflammation; S100A8; S100A9; psoriatic arthritis; psoriatic plaques; skin lesions.