Correlations of PTEN genetic polymorphisms with the risk of depression and depressive symptoms in a Chinese population

Gene. 2016 Dec 20;595(1):77-82. doi: 10.1016/j.gene.2016.09.034. Epub 2016 Sep 24.

Abstract

Objective: This study aimed to investigate the correlations of three common single nucleotide polymorphisms (SNPs) in the PTEN gene (rs701848 T>C, rs2735343 G>C and rs112025902 A>T) with the risk of depression and depressive symptoms in a Chinese population.

Methods: From July 2011 to June 2013, a total of 384 patients with depression and 400 healthy individuals were included in this study. These SNPs in the PTEN gene were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and direct sequencing. The Hamilton Depression Rating Scale (HAMD) was used to evaluate the severity of depression.

Results: The C allele of rs701848, the C allele of rs2735343 and the T allele of rs112025902 were associated with an increased risk of depression (odds ratio [OR]=3.814, 95% CI: 3.093-4.703, P<0.001; OR=2.642, 95% CI: 2.152-3.242, P<0.001; OR=2.882, 95% CI: 2.347-3.539, P<0.001; respectively). Depression patients carrying C allele (TC+CC) of rs701848 and carrying T allele (AT+TT) of rs112025902 had higher HAMD total scores and HAMD anxiety factor scores than those carrying TT genotype of rs701848 and carrying AA genotype of rs112025902 (all P<0.05). Furthermore, depression patients carrying C allele (GC+CC) of rs2735343 had lower HAMD total scores and HAMD factors associated with depression scores than those carrying GG genotype (both P<0.05). Logistic regression analysis revealed that rs701848, rs2735343 and rs112025902 polymorphisms in the PTEN gene may be independent risk factors of depression (relative risk [RR]=1.807, 95% CI=1.023-3.193, P=0.042; RR=1.759, 95% CI=1.033-2.995, P=0.038; RR=1.646, 95% CI=1.018-2.663, P=0.042; respectively).

Conclusion: Our findings provide evidence that rs701848, rs2735343 and rs112025902 polymorphisms in the PTEN gene may be correlated with the risk of depression and depressive symptoms in the Chinese population.

Keywords: Depression; Depressive symptoms; Genetic polymorphisms; Hamilton Depression Rating Scale; PTEN; Risk factor.

Publication types

  • Clinical Trial
  • Multicenter Study

MeSH terms

  • Adult
  • Alleles*
  • China
  • Depression / genetics*
  • Female
  • Genotype*
  • Humans
  • Male
  • Middle Aged
  • PTEN Phosphohydrolase / genetics*
  • Polymorphism, Restriction Fragment Length*
  • Polymorphism, Single Nucleotide*
  • Risk Factors

Substances

  • PTEN Phosphohydrolase
  • PTEN protein, human