Co-transfer of blaNDM-5 and mcr-1 by an IncX3-X4 hybrid plasmid in Escherichia coli

Jian Sun; Run-Shi Yang; Qijing Zhang; Youjun Feng; Liang-Xing Fang; Jing Xia; Liang Li; Xiao-Yue Lv; Jia-Hong Duan; Xiao-Ping Liao; Ya-Hong Liu

doi:10.1038/nmicrobiol.2016.176

Co-transfer of bla_NDM-5 and mcr-1 by an IncX3-X4 hybrid plasmid in Escherichia coli

Nat Microbiol. 2016 Sep 26:1:16176. doi: 10.1038/nmicrobiol.2016.176.

Authors

Jian Sun^{1

2}, Run-Shi Yang^{1

2}, Qijing Zhang³, Youjun Feng⁴, Liang-Xing Fang^{1

2}, Jing Xia^{1

2}, Liang Li^{1

2}, Xiao-Yue Lv^{1

2}, Jia-Hong Duan^{1

2}, Xiao-Ping Liao^{1

2}, Ya-Hong Liu^{1

2

5}

Affiliations

¹ National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou 510642, China.
² College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
³ Department of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011, USA.
⁴ Department of Medical Microbiology and Parasitology, Zhejiang University School of Medicine, Zhejiang 310027, China.
⁵ Jiangsu Co-Innovation Centre for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu 225009, China.

PMID: 27668643
DOI: 10.1038/nmicrobiol.2016.176

Abstract

Carbapenem and colistin are the last-resort antibiotics used for treating multidrug-resistant Gram-negative pathogens. Here, we report, for the first time, co-transfer of resistance to both classes of antibiotics by a mobile IncX3-X4 hybrid plasmid in an Escherichia coli isolate. Spread of such a plasmid is of great concern for clinical therapy, and heightened efforts are needed to control its dissemination.