Cutaneous manifestations of graft-versus-host disease: role of the dermatologist

Int J Dermatol. 2017 Feb;56(2):131-140. doi: 10.1111/ijd.13381. Epub 2016 Sep 23.

Abstract

Graft-versus-host disease (GVHD) is the major complication of hematopoietic stem cell transplantation and is associated with high mortality in severe cases. The skin is one of the major organs affected in both acute and chronic GVHD. This review aims to elucidate the basic characteristics of GVHD, and the role and contribution of dermatologists in the care of patients with this condition.

Keywords: Graft-versus-host disease; hematology; immunology; leukemia; lymphoma; sclerosis; systemic disease; vacuolar interface dermatitis.

Publication types

  • Review

MeSH terms

  • Acute Disease
  • Calcineurin Inhibitors / therapeutic use
  • Chronic Disease
  • Dermatology*
  • Graft vs Host Disease / diagnosis*
  • Graft vs Host Disease / etiology
  • Graft vs Host Disease / therapy*
  • Hematopoietic Stem Cell Transplantation / adverse effects
  • Humans
  • Immunoglobulins, Intravenous / therapeutic use
  • PUVA Therapy
  • Photopheresis
  • Physician's Role*
  • Risk Factors
  • Skin Diseases / diagnosis*
  • Skin Diseases / etiology
  • Skin Diseases / therapy*
  • Steroids / therapeutic use

Substances

  • Calcineurin Inhibitors
  • Immunoglobulins, Intravenous
  • Steroids