Two New Clerodane Diterpenes from Tinospora sagittata

Guanhua Li; Wenbing Ding; Fanghao Wan; Youzhi Li

doi:10.3390/molecules21091250

Two New Clerodane Diterpenes from Tinospora sagittata

Molecules. 2016 Sep 19;21(9):1250. doi: 10.3390/molecules21091250.

Authors

Guanhua Li¹, Wenbing Ding^{2

3}, Fanghao Wan^{4

5}, Youzhi Li^{6

7}

Affiliations

¹ College of Plant Protection, Hunan Agricultural University, Changsha 410128, China. liguanhua@hunau.edu.cn.
² College of Plant Protection, Hunan Agricultural University, Changsha 410128, China. dingwenb119@hunau.edu.cn.
³ Hunan Co-Innovation Center for Utilization of Botanical Functional Ingredients, Changsha 410128, China. dingwenb119@hunau.edu.cn.
⁴ College of Plant Protection, Hunan Agricultural University, Changsha 410128, China. wanfanghao@caas.cn.
⁵ State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China. wanfanghao@caas.cn.
⁶ College of Plant Protection, Hunan Agricultural University, Changsha 410128, China. liyouzhi@hunau.edu.cn.
⁷ Hunan Co-Innovation Center for Utilization of Botanical Functional Ingredients, Changsha 410128, China. liyouzhi@hunau.edu.cn.

Abstract

Two new clerodane-type diterpenes, tinosporins C (1) and tinosporins D (2) were isolated from the stems of Tinospora sagittata (Oliv.), together with three known ones, columbin (3), tinophylloloside (4), and tinospinoside D (5). The structures of these compounds were determined on the basis of spectroscopic data interpretation, with that of the absolute configuration of compound 1 was assigned by experimental and calculated ECD spectra. The cytotoxicity and α-glucosidase inhibitory activities of isolated compounds were evaluated in vitro.

Keywords: Tinospora sagittata; clerodane diterpenes; α-glucosidase inhibitory activity.